How does Botox Work?

Botox blocks cholinergic transmission at the neuromuscular junction by inhibiting the release of acetylcholine (ACH) from peripheral nerve endings. It binds to cholinergic nerve terminals through translocation of the light chain part of the molecule into cytosol at the nerve terminal, and enzymatic cleaves to the SNAP25 protein needed for the release of ACH and muscle contraction (appearance of wrinkles).

Botox stays in the area where injected with a small diffusion across the muscle that relaxes the muscle that through contraction forms wrinkles in various facial areas. It has the potential to migrate from the area so proper placement is needed and a thorough knowledge of facial anatomy to fully understand
and utilize the product effectively. The results with Botox are evident in 5-10 days after the injection and will continue to effectively treat the area for up to 14 weeks.

Botox also has pain management uses for a number of muscular spasticity disorders and other pain disorders including orofacial pain. Besides inhibiting the release of acetylcholine (ACH) from peripheral nerve endings, Botox has a secondary effect in that it blocks or inhibits release of glutamate that
functions as the brains main excitatory neurotransmitter (CGRP). This explains why Botox reduces pain longer than its ability to reduce muscular problems deformities.

Bottom line is that Botox works for a number of muscle related, cosmetic, and pain related disorders. There are over (17) FDA Approved uses for Botox and is why Botox continues to be the #1 non-invasive aesthetic procedure performed in the United States for the past (15) years.